Inaugurated in 1934, it houses the Eighteenth-century Venetian Museum in its rooms, gathering frescoes, paintings and antiques from other palaces or museums. It was built in the second half of the seventeenth century by the architect Baldassare Longhena, who was also responsible for the construction of the Ca' Pesaro palace and the Santa Maria della Salute Basilica.

However, the grandiose project proved too ambitious for the Bon family, thus remaining unfinished, as the funds ran out before the second floor began. Only in 1751, long after Longhena's death, the palace was purchased by Giambattista Rezzonico, and he entrusted the work to complete it to the architect Giorgio Massari, one of the most famous of the time.

The unstoppable rise of the family led to the completion of the building in just six years, just in time to celebrate their son Charles, elected pontiff in 1758 with the name of Clement XIII.

Over the years the palace gradually lost all its furnishings, the Rezzonico family quickly died out due to the lack of male heirs, and during the following century the prestigious palace changed owners several times, until 1935 , when it is purchased by the city of Venezia to house art collections.

Among his most precious treasures, we remember the ceiling frescoes on the first floor by Gianbattista Tiepolo, with the canvas depicting Nobility and Virtue that break down ignorance, and on the second floor the collection of paintings of the Venetian life of the eighteenth century by Pietro Longhi and canvases by Francesco Guardi and Canaletto.

The main attraction of the building, however, is the Ballroom created by Giorgio Massari, and occupies the entire width of the building and is enriched by large golden candlesticks and inlaid furniture. Such a grand hall is unrivaled in Venezia, both for its size and for the quality of the pictorial decoration.